1) The .info file for skinr blocks. The label will be the option presented; the class will be the class applied.
2) The css class that would be applied if you select "2-column plain" in the dropdown pictured below
3) By selecting NineSixty grid values, we can position blocks on the fly within a given region.
Skinr allows us to choose a template and apply classes when we create a content type.
When it comes time to theme a site you are often working within a tight time-frame. Functionality is starting to come together, representative content is here and there; generally things are in a pretty fluid state. Or perhaps you are doing rapid prototyping, and need to have some flexibility to change your layout on the fly without mucking about in template files or stylesheets. Whether you are themeing a moving target, or riding the wave of a prototype, you need tools that allow you to do your job as efficiently as possible.